Table 4 List of digital oximetry biomarkers for the categories: desaturation measures and hypoxic burden.

25

ODI_x

The oxygen desaturation index as defined in Jung et al. and Behar et al.^50,51, by default x = 3

event/h

26

DL_μ

Mean of desaturations length (e.g., related work in Kulkas et al.⁴⁷)

s

27

DL_σ

Standard deviation of desaturations length (e.g., related work in Kulkas et al.⁴⁷)

s²

28

DDmax_μ

Mean of desaturations depth (e.g., related work in Kulkas et al.⁴⁷)

%

29

DDmax_σ

Standard deviation of desaturation depth (e.g. related work in Kulkas et al.⁴⁷)

%²

30

DD100_μ

Mean of desaturations depth using 100% SpO₂ level as baseline (e.g., related work in Terrill et al.¹⁰)

%

31

DD100_σ

Standard deviation of desaturations depth using 100% SpO₂ level as baseline (e.g., related work in Terrill et al.¹⁰)

%²

32

DS_μ

Mean of the desaturation slope

%/s

33

DS_σ

Standard deviation of the desaturation slope

(%/s)²

34

DAmax_μ

Desaturation area defined as the mean of the desaturation areas using the maximum SpO₂ value in each desaturation event as baseline⁴⁷

%*s

35

DAmax_σ

Standard deviation of desaturation area⁴⁷

(%*s)²

36

DA100_μ

Desaturation area: mean of desaturation area under the 100% SpO₂ level as baseline⁴⁷

%*s

37

DA100_σ

Standard deviation of desaturation area under the 100% SpO₂ level as baseline⁴⁷

(%*s)²

38

TD_μ

Mean of time between two consecutive desaturation events

sec

39

TD_σ

Standard deviation of time between two consecutive desaturation events

s²

40

POD_x

Time of oxygen desaturation event, normalized by the total recording time¹⁸, by default x = 3

s

41

AOD_max

The area under the oxygen desaturation event curve¹⁸, using the maximum SpO₂ value as baseline and normalized by the total recording time

%

42

AOD₁₀₀

Cumulative area of desaturations under the 100% SpO₂ level as baseline and normalized by the total recording time

%

43

CT_x

Cumulative time below the x% oxygen saturation level, by default x = 90. Introduced by Olson et al.⁵⁵

%

44

CA_x

Integral of SpO₂ below the x SpO₂ level normalized by the total recording time, by default x = AV

%