Table 4 SNP-based Heritability Estimates for CKD and renal function.

Phenotype	Cohort-Ethnicity	Study	N_cases /N_controls	LD Reference	Method	SNP-based Heritability (SE)
CKD	eMERGE-European	Present study	7,536/17,841	1KG-Europeans	LDSC	0.015 (0.010)
	eMERGE-AA	Present study	702/2,029	1KG-Africans	LDSC	0.092 (0.217)
	eMERGE-Transethnic	Present study	8,238/19,870	1KG-All	LDSC	0.044 (0.029)
CKD	CKDGen-European	Wuttke et al.	41,395/439,303	1KG-Europeans	LDSC	0.005 (0.0009)
	CKDGen-Transethnic	Wuttke et al.	64,164/561,055	1KG-All	LDSC	0.004 (0.0008)
	CKDGen-Transethnic	Pattaro et al.	12,385/104,780	1KG-All	LDSC	0.013 (0.004)
eGFR	CKDGen-European	Wuttke et al.	480,698	1KG-Europeans	LDSC	0.056 (0.003)
	CKDGen-Transethnic	Wuttke et al.	765,348	1KG-All	LDSC	0.043 (0.002)
	CKDGen-European	Pattaro et al.	133,814	1KG-Europeans	LDSC	0.081 (0.007)
	CKDGen-AA	Pattaro et al.	16,474	1KG-Africans	LDSC	0.035 (0.045)

We estimated SNP-based heritability of CKD and eGFR from the available genome-wide summary statistics using LDSC method and ancestry-matched linkage disequilibrium reference panels from 1000 Genomes Project (1KG). In addition to present study, we used GWAS summary statistics from the largest published studies of CKD and renal function, including Wuttke et al. (Nature Genetics, 2019) and Pattaro et al. (Nature Communications, 2016). The summary statistics were downloaded from the CKDGen website (https://ckdgen.imbi.uni-freiburg.de).

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