Fig. 2: Radiographic spectrum of two participants with microbiologically confirmed active TB.

Digital CXR images and the corresponding CAD4TBv5 heatmaps (blue colors mark normal lung fields and red marks TB-related abnormalities contributing to CAD4TB score). Participant 1 (a, b) was 62 years old, HIV-positive on ART, and had a CAD4TB v5 score of 95 which the radiologist assessed as abnormal and diagnostic of TB. Participant 2 (c, d) was 31 years old, HIV-negative, and had a CAD4TB v5 score of 39, which the radiologist assessed as normal. Both participants had positive liquid culture and XpertUltra (greater than trace) results, no TB symptoms, and no history of previous TB treatment.