Table 2 Features extracted from the digital biomarkers (DBs) for the development of ITA algorithm.

Delta (Δ)

Deviation in digital biomarker from baseline median value

DB_Detection – DB_{Baseline, Median}

Delta_Normalized

Delta normalized by baseline median value

((DB_Detection – DB_{Baseline, Median}) / DB_{Baseline, Median})

Delta_Standardized

Delta standardized by baseline median and interquartile range (IQR)

((DB_Detection – DB_{Baseline, Median}) / DB_{Baseline, IQR})

Z-score

Deviation in digital biomarker from baseline mean, standardized by baseline standard deviation (SD)

((DB_Detection – DB_{Baseline, Mean}) / DB_{Baseline, SD})

Average

Median

Maximum

Minimum

Range