Fig. 6: Absolute treatment effects for main outcomes.

Treatment effect heterogeneity for the main outcomes on the absolute scale of thiazide or thiazide-like diuretics compared to ACE inhibitors within strata of predicted acute MI risk. In a we present treatment effects on the absolute scale for acute MI within groups of predicted acute MI risk across all three databases. In b we present treatment effects on the absolute scale for hospitalization with heart failure within groups of predicted acute MI risk across all three databases. In c we present treatment effects on the absolute scale for stroke (both ischemic and hemorrhagic) within groups of predicted acute MI risk across all three databases. RG-1 represents the group of patients with acute MI risk below 1%; RG-2 represents the group of patients with acute MI risk between 1% and 1.5%; RG-3 represents the group of patients with acute MI risk larger than 1.5. Absolute treatment effects estimated in CCAE, MDCD, and MDCR are represented by blue, green, and orange circles, respectively. The bars represent 95% confidence intervals. Values above 0 favor thiazide or thiazide-like diuretics, while values below 0 favor ACE inhibitors.