Table 3 Comparison of performance in the internal set (n = 20,401).

From: Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging

Event and time point

AUC Full model (1)

AUC Perfusion abnormality (2)

AUC Clinical-only model (3)

p value (1) versus (2)

p value (1) versus (3)

p value (2) versus (3)

MACE at 1 year

0.78 (0.77, 0.79)

0.76 (0.75, 0.77)

0.69 (0.68, 0.71)

0.089

<0.001

<0.001

MACE at 3 years

0.76 (0.75, 0.77)

0.72 (0.71, 0.73)

0.72 (0.71, 0.73)

<0.001

<0.001

0.788

MACE at 5 years

0.76 (0.75, 0.77)

0.70 (0.69, 0.71)

0.73 (0.72, 0.74)

<0.001

<0.001

<0.001

Death at 1 year

0.80 (0.77, 0.82)

0.61 (0.58, 0.64)

0.76 (0.74, 0.79)

<0.001

0.002

<0.001

Death at 3 years

0.78 (0.76, 0.80)

0.62 (0.60, 0.64)

0.76 (0.74, 0.77)

<0.001

<0.001

<0.001

Death at 5 years

0.77 (0.76, 0.79)

0.61 (0.60, 0.63)

0.75 (0.74, 0.76)

<0.001

<0.001

<0.001

ACS at 1 year

0.73 (0.70, 0.76)

0.73 (0.69, 0.76)

0.70 (0.67, 0.73)

0.972

0.025

0.188

ACS at 3 years

0.70 (0.68, 0.72)

0.68 (0.66, 0.71)

0.68 (0.66, 0.70)

0.253

0.054

0.970

ACS at 5 years

0.70 (0.68, 0.71)

0.67 (0.65, 0.69)

0.68 (0.66, 0.69)

0.054

0.025

0.621

Revasc. at 1 year

0.79 (0.77, 0.80)

0.81 (0.80, 0.83)

0.70 (0.68, 0.71)

0.018

<0.001

<0.001

Revasc. at 3 years

0.78 (0.76, 0.79)

0.77 (0.75, 0.78)

0.71 (0.70, 0.73)

0.489

<0.001

<0.001

Revasc. at 5 years

0.77 (0.76, 0.78)

0.75 (0.73, 0.76)

0.71 (0.70, 0.73)

0.011

<0.001

<0.001

  1. All p values were obtained using DeLong’s test. The bold values represent statistically significant (p < 0.05) comparisons. Abbreviations: ACS acute coronary syndrome, AUC area under the receiver-operating curve, MACE major adverse cardiovascular event, Revasc. revascularization.
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