Table 4 Comparison of performance in the external testing set (n = 13,988).

From: Time and event-specific deep learning for personalized risk assessment after cardiac perfusion imaging

Event and time point

AUC Full model (1)

AUC Perfusion abnormality (2)

AUC Clinical-only model (3)

p value (1) versus (2)

p value (1) versus (3)

p value (2) versus (3)

MACE at 1 year

0.74 (0.73, 0.76)

0.71 (0.70, 0.73)

0.68 (0.66, 0.69)

<0.001

<0.001

0.001

MACE at 3 years

0.73 (0.72, 0.74)

0.69 (0.67, 0.70)

0.69 (0.68, 0.71)

<0.001

<0.001

0.341

Death at 1 year

0.77 (0.74, 0.80)

0.61 (0.58, 0.65)

0.75 (0.72, 0.78)

<0.001

0.320

<0.001

Death at 3 years

0.76 (0.73, 0.78)

0.61 (0.58, 0.64)

0.72 (0.70, 0.74)

<0.001

0.026

<0.001

ACS at 1 year

0.74 (0.70, 0.78)

0.69 (0.64, 0.74)

0.72 (0.68, 0.76)

0.021

0.426

0.343

ACS at 3 years

0.72 (0.69, 0.74)

0.65 (0.62, 0.68)

0.70 (0.68, 0.73)

<0.001

0.469

0.012

Revasc. at 1 year

0.74 (0.73, 0.76)

0.74 (0.72, 0.76)

0.66 (0.64, 0.68)

0.763

<0.001

<0.001

Revasc. at 3 years

0.72 (0.70, 0.74)

0.72 (0.70, 0.74)

0.67 (0.65, 0.69)

0.737

<0.001

<0.001

  1. All p values were obtained using DeLong’s test. The bold values represent statistically significant (p < 0.05) comparisons. Abbreviations: ACS acute coronary syndrome, AUC area under the receiver-operating curve, MACE major adverse cardiovascular event, Revasc. revascularization.
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