Table 1 Participants’ demographics and clinical characteristics, stratified by remission status.

From: Circadian rhythm biomarker from wearable device data is related to concurrent antidepressant treatment response

Variables

Remission Status

   

Non-Remitters

(N = 24, 60%)

Remitters

(N = 16, 40%)

Fisher’s exact test

t-test

(DF = 38)

MW-U test

N (%)

Mean

(SD)

Median

(IQR)

N

(%)

Mean

(SD)

Median

(IQR)

(P)

t (P)

z (P)

Treatment assignment

SSRI (vs. Placebo)

16 (67)

  

6 (38)

  

0.11

  

Demographic

Sex: F (vs. M)

17

(71)

  

11

(69)

  

1.00

  

Age (years)

 

30.24

(14.20)

24.30

(10.80)

 

32.18

(17.44)

22.95

(24.65)

 

−0.39

(0.70)

0.11

(0.91)

Clinical

Week0-HDRS

 

19.33

(4.94)

18.00

(5.00)

 

15.56

(3.85)

15.50

(4.50)

 

2.57

(0.01*)

2.30

(0.02*)

Week1-HDRS

 

15.92

(3.88)

15.50

(5.50)

 

13.50

(3.74)

14

(5)

 

1.96

(0.06)

1.79

(0.07)

Week8-HDRS

 

14.42

(5.18)

14.00

(6.50)

 

4.53

(2.19)

4.50

(3.50)

 

7.19

(<0.01*)

5.32

(<0.01*)

ΔHDRS1

 

−0.20

(0.20)

−0.19

(0.28)

 

−0.15

(0.29)

−0.22

(0.27)

 

−0.61

(0.54)

−0.07

(0.94)

ΔHDRS8

 

−0.32

(0.30)

−0.24

(0.41)

 

−1.39

(0.75)

−1.13

(0.48)

 

6.30

(<0.01*)

5.03

(<0.01*)

  1. Non-Remitters: Week8-HDRS > 7. Remitters: Week8-HDRS ≤ 7.
  2. HDRS Hamilton depression rating scale, Week0-HDRS Hamilton depression rating scale score at baseline, Week1-HDRS Hamilton depression rating scale score after first week of treatment, Week8-HDRS Hamilton depression rating scale score after eight weeks of treatment, ΔHDRS1: change in depression severity after first week of treatment, ln(Week1-HDRS/ Week0-HDRS), with a higher value indicating more depression symptoms and a lower value indicating improvement in depression. ΔHDRS8: change in depression severity after eight weeks of treatment, ln(Week8-HDRS/ Week0-HDRS), with a higher value indicating more depression symptoms and a lower value indicating improvement in depression. N sample size. DF degrees of freedom = 38 for all the variables in the t-test. MW-U test Mann–Whitney U test, SD standard deviation, IQR interquartile range (75th percentile – 25th percentile), SSRI selective serotonin reuptake inhibitor, F female, M male.
  3. The P-values that are statistically significant are indicated in bold for *P < 0.05 at α = 0.05.