Fig. 6: Test performance of PKG^® quatitative scores for the detection of observer-documented Off and Dyskinetic state.

a–c Test performance of mBKS transferred into motor diary Off state. a Receiver operating curve (ROC) analyses displaying the sensitivity and specificity of the 7m-TUGT results, mBKS and exactly timed mBKS recordings for diary classification with time frames of the 28 min (seven 2-min epoches before and 7 epoches after clinical rating) around the clinical ratings (mBKS_{timed (28)}) for the detection of observer-documented Off state and (b) the individual AUC values and Youden values of mBKS for the detection the detection of observer-documented Off state. c Test performance indices (sensitivity, specificity, Youden index, Cohen’s κ for the detection of observer-documented Off state by mBKS cut-offs. Note the standard cut-off value of 25 units used for clinical routine use. d–f Test performance of mDKS tranferred into motor diary Dyskinetic state. d ROC analyses displaying the sensitivity and specificity of mDKS and exactly timed mDKS recordings for diary classification with time frames of the 28 min (seven 2-minutes epoches before and 7 epoches after clinical rating) around the clinical ratings (mDKS_{timed (28)}) for the detection of observer-documented Dyskinetic state and (b) the individual AUC values and Youden values of mDKS for the detection the detection of observer-documented Dyskinetic state. c Test performance indices (sensitivity, specificity. Youden index, Cohen’s κ for the detection of observer-documented Dyskinetic state by mDKS cut-offs. g Correlation of individual AUC values of mBKS and mDKS for the detection of the respective motor state. Numbers in right corner of scatter plot represent Pearson correlation coefficient and P value. h Distribution of individual mBKS and mDKS cut-offs values for detection of the respective motor state as rated by the clinical observer estimated by ROC analyses normalized to the 50th percentile of normal subjects (mBKS: 25 units; mDKS: 4 units). i–l Temporal agreement between wrist-wearable accelerometer-based digital Parkinson’s Motor Diary (adPMD) ratings ratings and observer-documented motor states on the participant level using the various cut-offs. Sensitivites expressed in precent (i, k) and Cohen’s κ values (j, l) of adPMD ratings for the detection of observer-documented Off state and Dyskinetic state on the participant level. Displayed P-values are from from Friedmann tests with post-hoc Wilcoxon signed-rank tests with Bonferroni correction for multiple comparisons. Boxplots (h–l) are shown with a central mark at the median, bottom, and top edges of the boxes at 25^th and 75^th percentiles, respectively, whiskers out to the most extreme points within 1.5 times the interquartile range, and outliers scoring more than 1.5 × IQR but at most 3 × IQR outside the quartiles.Data are based on 2389 simultaneous half-hourly performed observer diary ratings, respectively with simultaneous PKG^® recordings from 63 participants from 2 consecutive days (8 a.m. to 6 p.m.). 7m-TUGT and timed PKG^® recordings were only performed in the German cohort (n = 40, 1361 half-hourly assessments).