Fig. 1: Summary of the study design. | npj Digital Medicine

Fig. 1: Summary of the study design.

From: An explainable machine learning-based phenomapping strategy for adaptive predictive enrichment in randomized clinical trials

Fig. 1: Summary of the study design.The alternative text for this image may have been generated using AI.

(a) Visual summary of the original IRIS and SPRINT trials. (b) Cumulative recruitment and (c) primary outcome event numbers across different simulated trial timepoints. The vertical dashed lines denote the interim analysis timepoints (green: first interim timepoint; purple: second interim analysis timepoint; black: third interim analysis timepoint). HOMA-IR homeostasis model assessment of insulin resistance, IRIS Insulin Resistance Intervention after Stroke, SPRINT Systolic Blood Pressure Intervention Trial, TIA transient ischemic attack.

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