Table 2 Predictive value of single features in the training cohort for GG ≥ 2 prostate cancer
Predicting grade group ≥ 2 prostate cancer | ||||
|---|---|---|---|---|
GG ≤ 1 PCa | GG ≥ 2 PCa | p-value | ROC AUC (CI) | |
Patients, n | 1270 (58%) | 921 (42%) | ||
African American, n (%) | 31 (2.4%) | 35 (3.8%) | 0.076 | 0.51 (0.50 - 0.51) |
Asian, n (%) | 93 (7.3%) | 48 (5.2%) | 0.052 | 0.51 (0.50 - 0.52) |
Hispanic, n (%) | 12 (0.94%) | 9 (0.98%) | 1.0 | 0.50 (0.50 - 0.50) |
Native American, n (%) | 1 (0.079%) | 1 (0.11%) | 1.0 | 0.50 (0.50 - 0.50) |
White, n (%) | 923 (73%) | 651 (71%) | 0.29 | 0.51 (0.49 - 0.53) |
Family history PCa, n (%) | 281 (22%) | 178 (19%) | 0.29 | 0.51 (0.49 - 0.53) |
Prior negative biopsy, n (%) | 428 (34%) | 183 (20%) | <0.0001 | 0.57 (0.55 - 0.59) |
Number of prior negative biopsies, mean (SD) | 0.45 (0.73) | 0.26 (0.56) | <0.0001 | 0.57 (0.55 - 0.59) |
DRE, n (% abnormal) | 136 (11%) | 265 (29%) | <0.0001 | 0.58 (0.56 - 0.60) |
Age, yr, median (IQR) | 63 (58 - 68) | 66 (61 - 71) | <0.0001 | 0.60 (0.58 - 0.63) |
PSA, ng/ml, median (IQR) | 6.2 (4.6 - 8.5) | 7.7 (5.5 - 11) | <0.0001 | 0.63 (0.61 - 0.65) |
Free PSA, ng/ml, median (IQR) | 1.0 (0.70 - 1.5) | 0.95 (0.66 - 1.5) | 0.19 | 0.52 (0.49 - 0.54) |
% Free PSA, median (IQR) | 17 (13 - 22) | 12 (9.0 - 17) | <0.0001 | 0.69 (0.67 - 0.71) |
