Fig. 5: Identified repurposable drug candidates for preventing PD progression by targeting subtype-specific molecular changes. | npj Digital Medicine

Fig. 5: Identified repurposable drug candidates for preventing PD progression by targeting subtype-specific molecular changes.

From: Identification of Parkinson’s disease PACE subtypes and repurposing treatments through integrative analyses of multimodal data

Fig. 5: Identified repurposable drug candidates for preventing PD progression by targeting subtype-specific molecular changes.

a Gene set enrichment analysis (GSEA) based on subtype-specific gene modules with bulk RNA-seq data of individuals and transcriptomics-based drug-gene signature data in human cell lines identified repurposable drug candidates for different PD pace subtypes. Treatment effect estimation using the INSIGHT data within the broad PD population (b) and probable PD-R population (c). Treatment effect estimation using the OneFlorida+ data within the broad PD population (d) and probable PD-R population (e). aThe drug doesn’t have sufficient patient data (<100) for analysis. bThe drug does not have sufficient balanced emulated trials (<10). NT indicates the number of eligible PD patients who received the tested drug after PD initiation.

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