Fig. 8: Scoring methods for patient-trial matching score.

a Simple counting: In this approach, the total number of criteria met is counted and normalized by the total number of conditions. b Iterative tier: Here, we move through all the criteria by categorizing them into tiers. While traversing the nodes, if we encounter a violation (criteria unmet), we stop and use the number of criteria met till that point and normalize it by the total number of conditions. c Weighted tier: Similar to the iterative tier, this method also utilizes tiers, but instead of stopping at the first violation, it continues through the entire tree. It assigns greater importance to the first tier and progressively less weight to lower tiers.