Fig. 4: Forest plot for outcome fatigue/physical health.

Plot representing comparison of self-guided digital interventions versus controls (divided by therapeutic framework and active versus non-active controls) for outcome fatigue/physical health at the end of the intervention. Data was pooled from eight comparisons (n = 870). Only cognitive training (k = 3), cognitive rehabilitation (k = 4), and virtual reality (k = 1) reported data on fatigue/physical health outcomes. The random-effects meta-analysis found only a marginally significant effect of all self-help interventions compared to controls (g = −0.27 (95%CI −0.53 to −0.02; p = 0.03, I² = 66%).