Fig. 4: Consensus DAG calculated in Cohort 3.

Cohort 3 included N = 2,312 CID cases (of which 797 with pneumonia) and 2312 matched controls (with no PI), both with and without pneumonia. We visualize up to 2 direct parent levels and up to 2 direct child levels away from CID diagnosis. Up to 1 direct parent level for each direct child and up to 1 direct child level for each direct parent are included. DAG directed acyclic graph; NEC not elsewhere classified; NOS not otherwise specified; IM immune mechanism; bcc blood cell count; CID combined immunodeficiency; PI primary immunodeficiency.