Fig. 1: Psychological questionnaires results.

A Percent change from pre-to-post intervention in each questionnaire, by group. Significant group-by-time interaction effects were found in the levels of CES-D (depression scale), STAIS-5 (situational anxiety), BRCS (resilience) and MHC-SF (well-being). Bars represent the mean; error bars represent the SEM. Extreme values were clipped at [-50,50] for visualization purpose only. A favorable result is represented by a reduction of scores in the CES-D, STAIS-5, STAIT-5 and PSS scales, and by an increase in scores in the BRCS and the MHC-SF scores. See supplementary Table 3 for details. B Correlation network diagram of psychological questionnaires in the Test Group. Nodes represent different questionnaires, with edges indicating significant correlations between individual changes from pre to post intervention. Edge thickness corresponds to the strength of the correlation, while edge color represents the correlation direction, ranging from blue (negative correlation, -1.0) to red (positive correlation, +1.0). Larger nodes indicate questionnaires with higher overall correlation strength. Edge locations maintain relative similarities among immune mediators using MDS (See methods). The dense network structure suggests that changes in psychological measures in the test group were systematic rather than incidental. C Questionnaire scores in the low-intensity follow-up Test group (n = 44), pre-intervention, post-intervention and after the low-intensity follow-up period. Bars represent the mean; error bars represent the SEM. Significant differences between measurements are indicated. See supplementary Table 5 for details. All p values are FDR corrected for multiple comparisons, *p < 0.05, **p < 0.01, ***p < 0.001.