Table 2 Description of patient clusters, size (N) and median age (age of individuals at the time of their last record) and follow-up time in female and male CPRD participants
Cluster | Cluster description | N (%) | Median age (IQR), years | Median follow-up (IQR), years |
|---|---|---|---|---|
Females | ||||
Low disease burden (LB) | 650,897 (20.3) | 57 (49–70) | 27 (19–38) | |
LB1 | Low disease burden and low prevalence of risk factors | 291,665 (9.1) | 57 (48–70) | 28 (19–39) |
LB2 | Low disease burden, high prevalence of smoking and asthma | 190,005 (5.9) | 59 (50–70) | 27 (18–39) |
LB3 | Low disease burden, high prevalence of smoking/alcohol or drug misuse | 169,227 (5.3) | 57 (49–68) | 27 (18–37) |
Cardiometabolic (CM) | 601,704 (18.8) | 83 (74–89) | 30 (21–42) | |
CM1 | Multiple cardiovascular conditions, COPD, CKD, hypertension, diabetes, gout, dementia | 240,443 (7.5) | 85 (78–90) | 29 (18–45) |
CM2 | Multiple cardiovascular conditions, dementia, Parkinson’s disease | 194,004 (6.1) | 85 (76–91) | 28 (16–43) |
CM3 | Ischaemic heart disease, hypertension, CKD, arrythmia | 167,257 (5.2) | 76 (66–85) | 29 (18–44) |
Mental health (MH) | 1,138,738 (35.6) | 60 (51–74) | 30 (21–42) | |
MH1 | Multiple mental health conditions, high prevalence of smoking/alcohol or drug misuse | 246,272 (7.7) | 64 (54–76) | 30 (21–42) |
MH2 | Multiple mental health conditions, epilepsy, multiple sclerosis and other neurological conditions, smoking & obesity | 240,490 (7.5) | 67 (56–79) | 34 (24–46) |
MH3 | Eating disorders, several mental health conditions, low prevalence of cardiovascular conditions and risk factors | 239,858 (7.5) | 50 (45–56) | 26 (18–36) |
MH4 | Anxiety, depression and mixed conditions of intermediate prevalence | 226,129 (7.1) | 66 (55–78) | 31 (22–44) |
MH5 | Anxiety, depression and IBD | 185,989 (5.8) | 60 (51–74) | 31 (23–42) |
Mixed (MIX) | 683,135 (21.3) | 72 (60–83) | 29 (19–43) | |
MIX1 | Cancer, dementia, osteoarthritis, osteoporosis | 250,093 (7.8) | 76 (67–85) | 28 (17–43) |
MIX2 | Dementia, hearing impairment, osteoporosis, multiple sclerosis | 241,945 (7.6) | 69 (57–81) | 31 (21–44) |
MIX3 | Cancer, osteoarthritis, Meniere’s disease | 191,097 (6.0) | 68 (56–80) | 28 (18–41) |
Respiratory (RES) | 126,756 (4.0) | 64 (53–76) | 29 (20–42) | |
RES1 | Asthma, COPD, IBD and connective tissue disease | 126,756 (4.0) | 64 (53–76) | 29 (20–42) |
Males | ||||
Low disease burden | 386,484 (14.6) | 57 (49–68) | 28 (18–41) | |
LB1 | Low disease burden and low prevalence of risk factors, except congenital disease and melanoma | 140,398 (5.3) | 57 (50–67) | 30 (20–43) |
LB2 | Low disease burden | 129,687 (4.9) | 59 (50–70) | 27 (18–39) |
LB3 | Low disease burden, high prevalence of asthma | 116,399 (4.4) | 56 (48–67) | 27 (17–40) |
Cardiometabolic | 914,067 (34.6) | 74 (64–83) | 27 (17–41) | |
CM1 | Diabetes, gout, obesity | 209,963 (7.9) | 65 (55–76) | 29 (20 –42) |
CM2 | Multiple cardiovascular conditions, COPD, CKD, diabetes, gout | 170,306 (6.4) | 80 (72–86) | 28 (18–42) |
CM3 | Multiple cardiovascular conditions, cancer, COPD, CKD, dementia, Parkinson’s disease | 155,216 (5.9) | 81 (72–87) | 28 (17–42) |
CM4 | Multiple cardiovascular conditions (except heart failure), CKD, diabetes | 154,298 (5.8) | 71 (63–79) | 27 (18–41) |
CM5 | Multiple cardiovascular conditions, cancer, diabetes, dementia, Parkinson’s disease | 113,398 (4.3) | 77 (68–85) | 21 (12–33) |
CM6 | Diabetes, hypertension, CKD | 110,886 (4.2) | 69 (60 –77) | 26 (17–40) |
Mental health | 525,461 (19.9) | 59 (51–70) | 29 (20 –41) | |
MH1 | Multiple mental health conditions, high prevalence of smoking/alcohol or drug misuse | 204,626 (7.7) | 58 (50–68) | 28 (19–40) |
MH2 | Multiple mental health conditions, drug or alcohol misuse, epilepsy and other neurological conditions, smoking | 189,899 (7.2) | 66 (56–76) | 31 (22–44) |
MH3 | Multiple mental health conditions, including schizophrenia, high prevalence of smoking/alcohol or drug misuse and chronic liver disease | 130,936 (4.9) | 54 (47–62) | 27 (18–39) |
Mixed | 567,472 (21.4) | 65 (54–76) | 28 (19–41) | |
MIX1 | Cancer, infectious disease and respiratory disease | 241,920 (9.1) | 71 (59–81) | 30 (20–44) |
MIX2 | Gout, osteoarthritis, smoking | 166,641 (6.3) | 60 (51–72) | 28 (19–40) |
MIX3 | Connective tissue disease, gout, osteoarthritis | 158,911 (6.0) | 62 (52–72) | 26 (17–38) |
Respiratory | 251,766 (9.5) | 63 (52–74) | 29 (20–42) | |
RES1 | Asthma, bronchiectasis and COPD | 132,836 (5.0) | 63 (53–74) | 29 (19–42) |
RES2 | Asthma, bronchiectasis, COPD, IBD and connective tissue disease | 118,930 (4.5) | 62 (52–74) | 29 (20–42) |
