Table 1 Patient characteristics and compartmental distribution of OA progression with sex-based comparisons

From: Osteoarthritis progression pattern based on patient specific characteristics using machine learning

Variable

Total (N = 833)

Sex

Total (N = 833)

Sex

Male (N = 167)

Female (N = 666)

P-value

Male (N = 167)

Female (N = 666)

P-value

Demographic factors

OA Classification (final visit)

Age (years, initial visit)

57.9 ± 9.4

56.1 ± 11.5

58.4 ± 8.7

NS

 Unicompartmental OA

479 (57.5%)

95 (56.9%)

384 (57.7%)

NS

Age (years, final visit)

68.8 ± 9.2

67.0 ± 10.8

69.3 ± 8.7

NS

 MTF OA

449

88

361

NS

Sex (male/female)

167/666

   

 LTF OA

18

5

13

NS

BMI (kg/m2)

24.7 ± 3.2

25.0 ± 3.0

24.6 ± 3.2

NS

 PF OA

12

2

10

NS

BMD (lowest T-score)

−1.5 ± 1.2

−1.3 ± 1.2

−1.6 ± 1.2

NS

 Tricompartmental OA

354 (42.5%)

72 (43.1%)

282 (42.3%)

NS

Metabolic disease

509 (61.1%)

113 (67.7%)

396 (59.5%)

NS

 JSN-dominant

43

6

37

NS

 HTN

457 (54.9%)

102 (61.1%)

355 (53.3%)

NS

 O-dominant

141

31

110

NS

 DM

210 (25.2%)

57 (34.1%)

153 (23.0%)

0.003

 Indeterminate

170

35

135

NS

 Dyslipidemia

332 (39.9%)

83 (49.7%)

249 (37.4%)

0.004

     

Other comorbidities

216 (25.9%)

43 (25.7%)

173 (26.0%)

NS

     

Follow-up period (months)

10.9 ± 3.4

10.9 ± 4.1

10.9 ± 3.2

NS

     
  

Initial visit (N = 833)

  

Final visit (N = 833)

    

OARSI grade for radiographic factors

JSN (0/1/2/3)

MTF

 

296/530/7/0

  

26/414/259/134

    

LTF

 

806/20/7/0

  

742/58/23/10

    

PF

 

760/71/2/0

  

452/257/105/19

    
     

26/414/259/134

    

Osteophyte (0/1/2/3)

MF

 

448/320/65/0

  

85/213/348/187

    

LF

 

671/157/5/0

  

415/129/237/52

    

MT

 

410/391/32/0

  

118/338/340/37

    

LT

 

678/148/7/0

  

405/185/192/51

    

PF

 

601/229/3/0

  

366/209/228/30

    
  1. OA osteoarthritis, NS not significant, BMI body mass index, BMD bone mineral density, HTN hypertension, DM diabetes mellitus, OARSI Osteoarthritis Research Society International, JSN joint space narrowing, MTF medial tibiofemoral, LTF lateral tibiofemoral, PF patellofemoral, MF medial femoral condyle, LF lateral femoral condyle, MT medial tibial plateau, LT lateral tibial plateau, O-dominant osteophyte-dominant, JSN-dominant joint space narrowing-dominant.
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