Table 1 Examples for digital twins in medicine and healthcare

From: The role of digital twins in P4 medicine: A paradigm for modern healthcare

Subject

Reference

Article type

Content

Cardiology

36

C

Concepts in a digital twin model of the heart (2021).

Clinical oncology

37

R

Integrating medical imaging with mechanism-based, tissue-scale mathematical modeling (2022).

T1 diabetes

16

A

Closed-loop system of glucose metabolism functioning as an artificial pancreas (2019).

T2 diabetes

38

A

DT for chronic kidney disease (CKD) identification utilizing generalized metabolic fluxes (GMF) (2024).

Multiple sclerosis

39

R

Improve diagnosis, monitoring, therapy, and enabling prevention of disease progression (2021).

Viral infection

40

P

Personalized computer simulations of infection could allow more effective treatments (2021).

Immune system

41

P

Roadmap for building a prototype of an immune digital twin (2022).

Oncology

42

A

DT integrating mutation, miRNA expression, imaging, and clinical data for kidney and colon cancer (2024).

Healthcare

43

R

DT multi-agent simulation, monitoring the patient’s personal health indicators and their development (2025).

Mental health

44

A

DT for the detection of mental health conditions through dialog-based natural language processing systems (2024).

Critical Care

45

A

Optimize critical care workflows to monitor physical entities in the Critical Care Unit (2025).

Drug development

46

P

Drug Development Digital Twin (DDDT) for drug discovery, testing and repurposing (2022).

  1. A: Article, P: perspective, C: comment, R: review.