Table. 1 Baseline characteristics

From: Harnessing machine learning for the development, validation, and prognostic evaluation of MASHRisk score: insights from a multicohort study

Characteristics

Training cohort (n = 218)

Validation cohort (n = 93)

Test cohort 1 (n = 96)

Test cohort 2 (n = 26,256)

Prognosis cohort (n = 390,574)

Male

68 (31%)

45 (48%)

68 (71%)

12,605 (48%)

180,501 (46%)

Age

30.79 (11.35)

31.65 (9.87)

41.14 (11.79)

54.91 (7.51)

56.56 (8.09)

BMI

39.05 (7.42)

39.54 (6.43)

26.85 (3.65)

26.48 (4.13)

27.42 (4.77)

ALT

48.96 (39.82)

53.11 (34.16)

73.99 (60.18)

22.93 (13.77)

23.50 (13.98)

AST

35.86 (22.68)

38.97 (24.62)

48.45 (33.75)

25.69 (9.91)

26.14 (9.96)

GGT

46.65 (32.30)

57.50 (45.22)

75.04 (82.75)

33.39 (32.51)

37.21 (40.87)

Albumin

44.03 (3.34)

44.24 (3.10)

46.46 (3.57)

45.43 (2.52)

45.22 (2.61)

Total bilirubin

10.63 (4.42)

10.62 (3.61)

14.56 (6.95)

9.39 (4.56)

9.11 (4.36)

Uric acid

425.09 (118.70)

442.64 (127.14)

412.03 (116.85)

5.30 (1.22)

5.41 (1.38)

HbA1c

6.05 (1.15)

6.21 (1.17)

6.41 (1.65)

5.36 (0.47)

5.45 (0.61)

Triglycerides

2.10 (1.12)

2.20 (1.04)

2.60 (1.62)

1.64 (0.94)

1.75 (1.02)

Total cholesterol

5.10 (0.92)

5.14 (1.05)

5.09 (1.17)

5.73 (1.08)

5.70 (1.14)

HDL-C

1.16 (0.22)

1.17 (0.21)

1.00 (0.22)

1.48 (0.38)

1.45 (0.38)

LDL-C

3.24 (0.63)

3.23 (0.74)

3.06 (0.89)

3.58 (0.83)

3.56 (0.87)

MASH

96 (44%)

45 (48%)

43 (45%)

1168 (4.4%)

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  1. Data are presented as the median (SD) or n (%).
  2. BMI body mass index, ALT alanine aminotransferase, GGT gamma-glutamyl transferase, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, HbA1c glycated hemoglobin, AST aspartate aminotransferase, MASH metabolic dysfunction-associated steatohepatitis.