Fig. 7: Spatial metabolomic and pathway enrichment analysis of endothelial cells in LUAD samples. | npj Digital Medicine

Fig. 7: Spatial metabolomic and pathway enrichment analysis of endothelial cells in LUAD samples.

From: Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer

Fig. 7: Spatial metabolomic and pathway enrichment analysis of endothelial cells in LUAD samples.The alternative text for this image may have been generated using AI.

a Spatial distribution of lactate in LUAD samples from high- and low-lactate groups revealed by spatial metabolomics. b UMAP visualization showing distinct metabolic profiles across the two groups. c Differential expression of metabolites in endothelial cells between high- and low-lactate LUAD samples. KEGG pathway enrichment analysis of metabolites significantly upregulated (d) and downregulated (e) in panel (c). f GSEA demonstrating enrichment of autophagy-related metabolic pathways in endothelial cells from the high-lactate group.

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