Fig. 8: TCGA survival analysis of endothelial subtypes in LUAD samples. | npj Digital Medicine

Fig. 8: TCGA survival analysis of endothelial subtypes in LUAD samples.

From: Machine learning-enabled spatial multi-omics uncovers lactate-driven targets and tumor microenvironmental reprogramming in cancer

Fig. 8: TCGA survival analysis of endothelial subtypes in LUAD samples.The alternative text for this image may have been generated using AI.

Kaplan–Meier survival curves showing that endothelial cell subclusters 1 (a) and 9 (b) are significantly associated with poor prognosis in LUAD patients. Top 10 enriched GO pathways of genes upregulated (c) and downregulated (d) in endothelial cell subcluster 1 from high- vs. low-lactate LUAD samples. e Immunofluorescence validation of increased FN1, ENG, and MMP2 expression in high-lactate LUAD samples.

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