The introduction of single abiological catalytic groups enables enzymes to catalyse new-to-nature chemical transformations. Now, this concept is extended to two abiological groups in a single protein scaffold to allow synergistic catalysis in a stereoselective Michael addition reaction.
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Ren, X., Fasan, R. Synergistic catalysis in an artificial enzyme. Nat Catal 3, 184–185 (2020). https://doi.org/10.1038/s41929-020-0435-z
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DOI: https://doi.org/10.1038/s41929-020-0435-z
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