Extended Data Fig. 1: Comparison of denoising methods for tomographic reconstruction and resolution estimation.
From: Three-dimensional nanoimaging of fuel cell catalyst layers
a, Multi-orthoslice overview of a raw reconstruction of an aggregate from the LSC7 sample and comparison with the same volume denoised with the cryo-CARE method. Scale cube is 203 nm3. b, Representative areas from the reconstruction and denoising results following a median filter with a 2×2 pixels kernel, the BM3D algorithm69,70, and the cryo-CARE method. Median and BM3D were applied plane-by-plane while cryo-CARE is a volumetric method. Scale bar is 20 nm. c, Line profiles plotted from the area 2 as shown by the corresponding arrows in (b). d, Metric Q comparison71. Higher values indicate lower levels of noise and blur in 252 px2 anisotropic patches of an image. e, Fourier shell correlation plots computed from the even and odd volumes before (raw) and after denoising with cryo-CARE. The resolution was estimated at the half-bit criterion.
