Fig. 1: Biosynthetic pathway of lincosamide antibiotics.

a, Structures of lincosamide antibiotics. b, Amide bond formation in the biosynthesis of 1 and 4. c, The enzyme reaction of CcbD with 8.

a, Structures of lincosamide antibiotics. b, Amide bond formation in the biosynthesis of 1 and 4. c, The enzyme reaction of CcbD with 8.