Extended Data Fig. 1: Enzymatic and chemical studies of the five-membered THF ring formation. | Nature Catalysis

Extended Data Fig. 1: Enzymatic and chemical studies of the five-membered THF ring formation.

From: Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis

Extended Data Fig. 1: Enzymatic and chemical studies of the five-membered THF ring formation.

a, Proposed steps of SoBcmB-catalysed five-membered THF ring formation. b, HPLC chromatograms of SoBcmB-catalysed reactions using compounds 1 and 1a as substrates and chemical transformation of compound 1a with mCPBA. The experiments were repeated independently at least three times with similar results.

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