Extended Data Fig. 3: Crystal structures of SoBcmB. | Nature Catalysis

Extended Data Fig. 3: Crystal structures of SoBcmB.

From: Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis

Extended Data Fig. 3

Proteins are shown as sticks in slate and different ligands are shown in different colours. Ligands were modelled into electron density (omit map, grey), contoured to 3.0 σ. The key hydrogen-bond interactions are labelled in black dashed lines. Water molecules that interacted with ligands are shown as a sphere (red), labelled W1, W2, and W3 and the water coordinated with iron is labelled W. a, Overall structure of SoBcmB•FeII•αKG (slate) binary complex (PDB code 8HIV) is shown as a monomer (shown as a cartoon, left). The detail of the active site is shown as the stick and hydrogen bonding interactions are labelled by dash lines in black (right). b, SoBcmB•FeII•αKG•1 (yellow) quaternary complex structure (PDB code 7V2X). c, SoBcmB•FeII•αKG•1a (magenta) quaternary complex structure (PDB code 7V3E). d, SoBcmB•FeII•αKG•1d (orange) quaternary complex structure (PDB code 7V34).

Back to article page