The enantioselective formation of Csp3–Csp3 bonds is still a substantial challenge in the synthesis of complex molecules. Now, a photocatalytic system has been developed for the enantioselective alkylation of α-amino Csp3−H bonds that promotes the generation of two different alkyl radicals, followed by their cross-coupling at a chiral nickel centre.
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Chae, J.B., Holm, A.R. & Mirica, L.M. Radical control for enantioselective Csp3–Csp3 cross-coupling. Nat Catal 7, 857–859 (2024). https://doi.org/10.1038/s41929-024-01208-2
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DOI: https://doi.org/10.1038/s41929-024-01208-2
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