Fig. 2: Application of ruthenium-catalysed ortho-silylmethylation to a range of arenes. | Nature Catalysis

Fig. 2: Application of ruthenium-catalysed ortho-silylmethylation to a range of arenes.

From: Precision installation of silyl synthetic handles within arenes by regiocontrolled ruthenium C(sp2)–H functionalization

Fig. 2: Application of ruthenium-catalysed ortho-silylmethylation to a range of arenes.

Reaction scope using (bromomethyl)trimethylsilane (3). Reactions were performed on a 0.25-mmol scale using 5 mol% [Ru] unless otherwise noted. All yields correspond to isolated compounds. a10 mol% [Ru] and 60 mol% PhP(O)O2K2 were used. b36-µmol scale. c180-µmol scale. d87-µmol scale. TBDMS, tert-butyldimethylsilyl; PMB, para-methoxybenzyl; Ac, acetyl; Boc, tert-butyloxycarbonyl; WHO, World Health Organization.

Back to article page