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Enzymatic catalysis

Iminium catalysis meets Diels–Alderase

Nature Catalysis volume 8, pages 202–203 (2025)Cite this article

In the organocatalytic Diels–Alder (DA) reactions, a simple amine is used as a catalyst to form an iminium adduct as an electron-withdrawing group that speeds up reaction with the diene. Now iminium catalysis is identified in Diels–Alderase (DAase) reactions, enabling to substantially broaden the DAase platform.

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Fig. 1: Iminium-catalysed Diels–Alder (DA) reaction by SdnG.
The alternative text for this image may have been generated using AI.

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Authors and Affiliations

  1. Faculty of Agriculture, Setsunan University, Osaka, Japan

    Naoki Kato

  2. Department of Chemistry and Biotechnology, Graduate School of Engineering, Tottori University, Tottori, Japan

    Shingo Nagano

  3. Center for Research on Green Sustainable Chemistry, Tottori University, Tottori, Japan

    Shingo Nagano

Authors
  1. Naoki Kato
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  2. Shingo Nagano
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Correspondence to Shingo Nagano.

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The authors declare no competing interests.

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Kato, N., Nagano, S. Iminium catalysis meets Diels–Alderase. Nat Catal 8, 202–203 (2025). https://doi.org/10.1038/s41929-025-01312-x

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