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Biocatalysis

Triplet quenchers for energy-transfer photobiocatalysis

Nature Catalysis volume 8, pages 1131–1132 (2025)Cite this article

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Engineering protein catalysts represents an attractive approach for enantioselective energy-transfer photochemistry. By combining a genetically encoded photosensitizer in the protein catalyst and a judiciously selected triplet quencher to suppress the racemic background reaction in the solution, photobiocatalytic [2+2] cycloaddition offers improved enantiocontrol in a triplet sensitization catalysis.

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Fig. 1: Energy-transfer photobiocatalysis for asymmetric [2+2] cycloaddition reactions.

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Authors and Affiliations

  1. Department of Chemistry and Biochemistry, University of California, Santa Barbara (UCSB), Santa Barbara, CA, USA

    Wenzhen Fu & Yang Yang

  2. Department of Biological Engineering, University of California, Santa Barbara (UCSB), Santa Barbara, CA, USA

    Yang Yang

  3. Biomolecular Science and Engineering (BMSE) Program, University of California, Santa Barbara, CA, USA

    Yang Yang

Authors
  1. Wenzhen Fu
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  2. Yang Yang
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Correspondence to Yang Yang.

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The authors declare no competing interests.

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Fu, W., Yang, Y. Triplet quenchers for energy-transfer photobiocatalysis. Nat Catal 8, 1131–1132 (2025). https://doi.org/10.1038/s41929-025-01443-1

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