Fig. 4 | Communications Biology

Fig. 4

From: Assessment of susceptible chemical modification sites of trastuzumab and endogenous human immunoglobulins at physiological conditions

Fig. 4

LC/MS total ion current chromatograms of trypsin digested trastuzumab reference material vs. Protein G isolated endogenous human serum IgG pools. Sequence determination of tryptic peptides selected for quantification was achieved by LC–MS/MS. Peptides selected for quantification of Asn (N) deamidation, Asp (D) isomerization, and Met (M) oxidation are marked with arrows. Analytical quantification data are summarized in Table 4

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