Table 1 Replicating variants associated with DDH

From: Genome-wide association study of developmental dysplasia of the hip identifies an association with GDF5

SNP ID (chromosome: position)

Effect allele/other allele

Effect allele frequency (discovery stage)

Discovery odds ratio (95% CI)

Discovery P-value

Replication odds ratio (95% CI)

Replication P-value

Meta-analysis odds ratio (95% CI)

Meta-analysis P-value

rs143384 (20:34025756)

A/G

0.60

1.57 (1.40–1.77)

1.72 × 10−14

1.37 (1.24–1.51)

1.33 × 10−10

1.44 (1.34–1.56)

3.55 × 10−22

rs4740554 (9:13688437)

C/A

0.10

1.44 (1.22–1.71)

4.09 × 10−05

1.20 (1.03–1.39)

0.01

1.30 (1.16–1.45)

4.44 × 10−6

rs4919218 (10:100111392)

C/T

0.69

1.27 (1.13–1.43)

6.48 × 10−05

1.14 (1.03–1.25)

0.0089

1.19 (1.10–1.28)

4.38 × 10−6

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