Fig. 5

Overall structure of MakA and comparison of MakA with related structures. a A ribbon presentation of MakA where the coloring blends through the model from blue (N-terminus) to red (C-terminus). The tail subdomain comprises helices 1, 2, 3, 6 and the head subdomain comprises helices 2 and 5 and a β-sheet. The flexible regions that have not been modeled are depicted with dotted lines. The side putative gate-recognition motif (FTTP) is illustrated as stick models and indicated with an arrow. The head domain comprises helices 4 and 5 and a β-sheet. b Ribbon diagram of (i) MakA, (ii) Hbl-B⁴⁰ from B. cereus, (iii) NheA⁴¹ from B. cereus and (iv) the soluble form of ClyA⁴² from E. coli. The structures of MakA, Hbl-B, NheA, and ClyA are depicted in blue and the hydrophobic β-strands of MakA, Hhl-B, and ClyA are illustrated in green. The amphiphatic, but structurally equivalent β-strands of NheA are depicted in pink