Fig. 3
From: Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
NF1 minipigs develop optic pathway glioma-like lesions. a Axial T1-weighted MRI demonstrates a lesion at the level of the optic chiasm (white arrow) in a 9-month-old NF1 minipig. b Axial T1-weighted MRI of a normal optic chiasm from a 16-month-old NF1 minipig. c H&E staining of the optic pathway lesion from an NF1 minipig shows hypercellularity. d H&E staining of an optic nerve from an NF1 minipig. e H&E staining of an optic nerve from a wild-type minipig. f Iba1 immunohistochemistry of the optic pathway lesion from an NF1 minipig shows increased microglial infiltration. g Iba1 immunohistochemistry of an optic nerve from an NF1 minipig. h Iba1 immunohistochemistry of an optic nerve from a wild-type minipig. i Ki67 staining of an optic pathway lesion from an NF1 minipig shows a low proliferative index. j Ki67 staining of an optic nerve from an NF1 minipig. k Ki67 staining of an optic nerve from a wild-type minipig. Scale bars, 50 µM
