Table 2 Comparison of mouse, minipig, and human NF1-associated phenotypes1,4,5,22,23,80
From: Genetically engineered minipigs model the major clinical features of human neurofibromatosis type 1
NF1 animal model | Age at puberty | Lifespan | Average age of onset | ||||||
|---|---|---|---|---|---|---|---|---|---|
OPG | Cutaneous neurofibroma | Lisch nodule | CALM | Pheochromocytoma | Myeloid leukemia | Tibial diaphyseal narrowing | |||
Mouse (Mus musculus) | 6–8 weeks | 1–3 years | n/a | n/a | n/a | n/a | 15–28 months | 17–27 months | n/a |
Ossabaw minipig (Sus scrofa) | 5–6 months | 15 years | 9 months | 4 months | Pre-puberty | Birth | n/a | n/a | Pre-puberty |
Human | 10–15 years | 70–80 years | 3–5 years | 10–15 years | Pre-puberty | Birth | 39 years | 2 years | 6–12 months |
