Fig. 6

In vivo tumor imaging and pharmacokinetic study. a Optical imaging of HeLa tumor-bearing mice after the intravenous injection of TB@PMP micelles at different time. b Fluorescence images and c relative fluorescence intensity of the major organs and tumor of the TB@PMP micelles treated mice at 24 h postinjection (n = 3). Significant differences compared to the TB@PMP (+) group are indicated: ***p < 0.001. d The pharmacokinetics parameters of TB@PM and TB@PMP micelles (TB@PMP: 12.5 mg kg⁻¹ body weight, an equal paclitaxel dose of 2.2 mg kg⁻¹ and TB dose of 1.2 mg kg⁻¹) after intravenous injection