Fig. 1
Variation of the gut microbiota structure across normal weight and obese children is mirrored by changes in health indices. The PCoA plots (PCo1 and PCo3 axes used) in the lower part of the figure show four significantly different groups of subjects (C1–C4, p < 0.001), as defined by unweighted UniFrac microbiota analysis of normal weight children (T1_N, T3_N; left), the whole cohort (centre) and obese children (T1_O, T3_O; right). The top of the figure shows the Wiggum plots corresponding to the four groups from the whole cohort analysis, in which disc sizes indicate genus over-abundance compared to the average relative abundance in the whole cohort. Pie charts show the proportion and number of subjects per group (pink, T1 normal weight children that will develop obesity (T1_O); red, T3 obese children (T3_O); cyan, T1 normal weight children (T1_N); light blue, T3 normal weight children (T3_N)). For subject clustering (C1–C4), please see Supplementary Fig. 1. Curved arrows indicate a transition from health (blue) to an inflammatory state (red), as defined by the increase in several inflammatory markers (CRP, IL-6, IL-8, IL-15, TNF-α), as well as in triglycerides and diastolic blood pressure. Please see also Table 1
