Table 2 Tabular depiction of genes found to have ocular phenotypes arranged by the ocular tissue involved and the novelty of the gene or phenotype

From: Identification of genes required for eye development by high-throughput screening of mouse knockouts

Ocular tissue

Categorical genes (total)

Known gene (total)

Novel phenotype (total)

Novel gene (total)

Adnexa

8 (20)

0 (3)

0 (1)

8 (16)

Cornea

25 (46)

1 (6)

4 (4)

20 (36)

Iris

5 (19)

0 (6)

0 (1)

5 (12)

Lens

79 (113)

6 (13)

10 (13)

63 (87)

Vitreous

22 (40)

2 (4)

3 (4)

17 (32)

Retina

102 (139)

17 (24)

16 (20)

69 (95)

Optic nerve

4 (8)

0 (2)

0 (0)

4 (6)

Eye size

11 (18)

1 (1)

3 (4)

7 (13)

Neuro

13 (20)

0 (2)

1 (3)

12 (15)

AS Combo

24

5

3

16

PS Combo

6

1

1

4

Whole Eye

48

9

3

36

Total

347

42

44

261

  1. A total of 347 different genes were identified. Of these, 42 genes had phenotypes that have been previously described, 44 genes had phenotypes that differed from previously described ocular phenotypes, and 261 genes previously not known to cause ocular disease were found to have ocular phenotypes. AS Combo represents combination of multiple anterior segment structures (i.e., adnexa, cornea, iris, or lens), PS Combo represents combination of multiple posterior segment structures (i.e., vitreous, retina, or optic nerve), and Whole Eye represents phenotype spanning multiple ocular segments (e.g., anterior and posterior). Neuro represents an abnormality of the pupillary light reflex. In parentheses, the total number of genes affecting a given ocular tissue is shown including genes affecting multiple ocular tissues