Fig. 10 | Communications Biology

Fig. 10

From: The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release

Fig. 10

Stereo views of the DHFR:FH2:NADP(H) ternary complex. The disordered Met20 loop (residues between Ile14 and Pro21) is indicated as black dashed lines. The Fo–Fc omit map at a 3.0σ level is shown as red mesh. Secondary structures are shown as cartoons and ligands in a stick representation. Atoms are colored as follows: carbon (white), nitrogen (blue), oxygen (red), and phosphorous (orange)

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