Fig. 2 | Communications Biology

Fig. 2

From: The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release

Fig. 2

Comparison of the ligand structures of eDHFR:FH4 (green, top figure) and eDHFR:FH2 (orange, bottom figure) complexes. The Fo–Fc omit electron density maps contoured around the ligands are shown at 3.0σ level. The views on the right are rotated 90° counter clockwise about the vertical axis from the perspectives shown on the left. FH4 and FH2 are shown as sticks. The C6 carbon atom is colored in magenta, and its different hybridization states in FH4 and FH2 are indicated by magenta pointing arrows. All other atoms are colored as follows: oxygen in red, nitrogen in blue, carbon in green, and orange for FH4 and FH2, respectively. Only non-hydrogen atoms are shown for simplicity of viewing

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