Fig. 3
Two-dimensional (2-D) analysis for disease datasets from various neuropsychiatric disorders. a–h Results of the 2-D analysis of datasets for schizophrenia (a), ALS (b), Alzheimer’s disease (c), autism (d), Parkinson’s disease (e), bipolar disorder (f), Huntington’s disease (g), and major depressive disorder (h). Each point corresponds to the results of one independent study. Filled points indicate datasets from the postmortem brain or spinal cord (ALS) of patients, and open points indicate those from cultured neural cells from patient iPSCs. i The distribution patterns of the hiM- and hiI-indexes for all diseases analyzed. The extent of the changes in hiM-/hiI-indexes is assessed by the average distance of all datasets for each disease from the origin. Four diseases whose average distances from the origin are over 5.0 are shown as circular sectors, and the others are shown as points. The radii of the circular sectors indicate the average distance of all datasets in each disease from the origin, and the central angles of the circular sectors are the average deviation ± SEM from the unity line. Each point indicates the average distance from the origin and average deviation from unity line
