Fig. 6

Characterization of hSMC cell-remodeled humanized collagen gels. a–c SE images of the CFC, 2 and 4 weeks cell-free gels, respectively. d–f Panchromatic auto-CL images of the CFC, 2 and 4 weeks cell-free gel samples, respectively. g–i Corresponding distribution images of the blue deconvoluted component, and j–l the red deconvoluted component. m–o Corresponding deconvoluted CL histograms. The CFC data is shown as the reference and starting point of the remodeling process. Scale bars are 25 µm, and the FOV in b, c is 180 µm; each auto-CL hyperspectral scan was obtained with 200 × 200 pixels. Black labels refer to human fibrinogen complex signatures, light-blue labels refer to collagen signatures, and red labels indicate CL signatures from unidentified molecular content