Fig. 2

Human CCT5 and P. furiosus Pf-Cpn (Pf-CD1) superposed onto the crystal structure of Thermococcus strain KS-1 subunit α (1Q3Q). Left: The Pf-CD1 graphic representation (gold ribbon) was obtained in Swiss-Model (http://swissmodel.expasy.org/) and superposed onto the crystal structure of KS-1 subunit α (monomers are displayed in marine blue, violet, and deep teal colors as surface, and in cyan color as ribbon). The whole hexadecamer double-ring structure is depicted by a dotted line. Right: Magnified image of the superposed structures of the Pf-CD1 (gold ribbon) and Human CCT5 (orange ribbon) onto the KS-1 α subunit crystal structure (1Q3Q; cyan ribbon). Side chains of isoleucine at 138 of Pf-CD1 (blue), isoleucine at 138 of KS-1 subunit α (deep teal), and histidine at 147 of human CCT5 (red) are represented as ball and stick. AMP-PNP (β,γ-Imidoadenosine 5′-triphosphate lithium salt hydrate; green stick) and magnesium ion (yellow ball). (Reproduced with permission from ref. ⁴⁶, published under the CC-BY license)