Fig. 1
From: Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Offspring survival and RAGE-oxytocin interactions. Kaplan–Meier survival curves for offspring of WT (Ager+/+) and RAGE-null Ager−/− (knockout of the mouse gene for the receptor for AGEs) dams housed with their biological mothers (a; n = 40 WT pups/WT dams; 38 Ager−/−pups/Ager−/− dams), or transferred to different cages and housed with postpartum dams of the opposite genotype (b; n = 66 WT pups/Ager−/− dams; 66 Ager−/− pups/WT dams). P-values derived from log-rank calculations. c Surface plasmon resonance (BiaCore) assessment of oxytocin binding to immobilised human esRAGE. d, e Microtitre plate wells contain varying amounts of immobilised oxytocin (d) or esRAGE (e); added d esRAGE (1 μg/ml) or e oxytocin (100 μM) were detected immunochemically (n = 3). Values are mean ± SEM
