Fig. 7
From: Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Offspring survival in Ager−/− mice and behavioural characteristic. a Survival curves for biological offspring of WT (Ager+/+) dams with (solid black line, n = 45) or without (black dashed line, n = 40) re-expressed human RAGE (Tg). Survival curves for biological offspring of Ager−/− (KO) dams with (red solid line, n = 71) or without (red dashed line, n = 38) re-expression of human RAGE. P < 0.001. b Survival curves for offspring of dams deficient for RAGE in endothelial cells (EC-KO, n = 76) and WT (Ager+/+) dams (solid black line, n = 45). P < 0.001. P-values derived from log-rank calculations. c, d During light-dark transition tests, the greater distances travelled (c) and greater average speed (d) in the light zone exhibited by Ager−/− male mice were both reduced by intraventricular (V) but not subcutaneous (sc) injection of oxytocin (OT) (n = 14–16). e In open field tests that assess anxiety in a new environment, the total distance travelled during the first 5 min was determined for Ager−/− male mice before and after intraventricular (intraV) (5 min, 0.1 ng/μl × 3 μl/min) or nasal (100 ng/ml × 20 μl) administration of oxytocin (OT) (n = 4–5). ns, not significant. Values are mean ± SEM
