Fig. 3 | Communications Biology

Fig. 3

From: 90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin’s Lymphoma

Fig. 3

Tocixity assesmment in naïve B6 mice administered 90Y-NM600. a Longitudinal CBC panel and weight monitoring in mice injected 1.85, 4.63, or 9.25 MBq 90Y-NM600 IV. Mild, dose-dependent cytopenias were observed with a NADIR at day 10 p.i. and a three-week recovery period. Shaded areas represent the 95% CI of the normal values. No significant variation in weight was recorded in any of the different dose cohorts. b H&E staining of potential organs at risk was carried out in mice given the highest 90Y-NM600 IA (9.25 MBq) at days 5, 10, and 28 p.i. (n = 3). Day 5 shows a reduction in cellularity in the spleen white pulp and the bone marrow, which where largely recovered at day 10. Scale bar represents 100 μm. c Longitudinal panel of serum biomarkers indicative of systemic toxicity in mice injected 9.25 Mbq 90Y-NM600 (n = 3)

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