Fig. 7 | Communications Biology

Fig. 7

From: 90Y-NM600 targeted radionuclide therapy induces immunologic memory in syngeneic models of T-cell Non-Hodgkin’s Lymphoma

Fig. 7

Immunocompetent status affects the levels of complete response to 90Y-NM600 treatment. a Two groups of immunocompromised Rag2 KO were implanted with EL4 flank grafts then received IV injections of 5 × 107 T-cells from naïve wild-type mice (NV-Rag2 KO) or from wild type mice previously cured with 90Y-NM600 (CR-Rag2 KO), followed by a single dose of 90Y-NM600. WT control mice were implanted with EL4 cells and received no therapy. b Tumor growth curve of Rag2 KO mice bearing EL4 grafts treated with 9.25 MBq 90Y-NM600. Similar tumor eradication in both, non-transplanted NV-Rag2 KO and transplanted Rag2 ( + ) groups was observed at day 14 after treatment. c Overall survival was higher in CR-Rag2 KO mice, with 80% of the animals alive at day 70 post-injection of 90Y-NM600

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