Fig. 7
Model of the potential role of AP-1 and miR-200a in spinal cord regeneration. a After SCI, axolotl glial cells up-regulate expression of AP-1cFos/JunB, which functions to repress GFAP expression and to regulate downstream pathways that direct glial cells to divide, migrate and functionally repair the missing spinal cord tissue. Additionally, miR-200a is upregulated which represses c-Jun expression thereby blocking formation of the canonical AP-1cFos/cJun. b Inhibition of miR-200a during spinal cord regeneration results in higher levels of GFAP expression, ectopic expression of c-Jun in GFAP+ glial cells, upregulation of genes indicative of a glial scar like environment and a failure in axon regeneration
