Fig. 1 | Communications Biology

Fig. 1

From: Identification of evolutionarily conserved virulence factor by selective pressure analysis of Streptococcus pneumoniae

Fig. 1

Scheme for intra-species molecular evolutionary analysis. a Random genetic drift induces synonymous and non-synonymous mutations with equal probability. However, non-synonymous mutations in essential region are removed by host selection. b As a result of natural selection, synonymous substitutions are concentrated in important genes. Phylogenetic and molecular evolutionary analyses can detect significant accumulation of synonymous substitutions in codons of host proteins. Codon-based analysis yields much more information than nucleotide- or amino acid-based analyses

Back to article page